The period between 1965 and 1977, the directorship of Mr C.F. Jacot Guillarmod, was one of consolidation. The National Collection of Freshwater Organisms was transferred from the CSIR to the Museum. The Early Stone Age site at Amanzi was excavated and re-excavations were done at Wilton and Howison's Poort. Fort Selwyn was restored by the Cape Provincial authority and handed over to the Museum in 1977.
In 1977 Mr Jacot Guillarmod was succeeded by Mr Brian Wilmot and it was at this time that the Museum entered a new period of growth. De Beers Consolidated Mines Limited purchased and restored the Observatory and the Priest's House and donated them to the Museum. The Old Provost military prison was restored by the Cape Province.
The freshwater fish collections of the Transvaal and Cape Nature Conservation authorities, the Natal Museum and the South African Museum were transferred to the Albany Museum (the latter two on loan) making it the largest collection in southern Africa. Museum staff started teaching short courses at the University and, in 1983, the Museum became an Affiliated Research Institute of Rhodes University. The close relationship with the University was expanded with the consolidation of the herbaria of the two institutions and the formation of the Selmar Schonland Herbarium, housed in the Natural Sciences Museum.